Bubbling up on more than 100 islands in a lagoon off the Adriatic, Venice is an absolutely unique and unquestionably beautiful city. The weight of its opulent architecture – bulbous domes, gothic spires, and lacy marble – may be sinking the city by 10 inches a century, but your local guide will make sure you don’t sink out of sight as you tour the intricate labyrinth of streets and bridges. Step into Piazza San Marco, an airy expanse of arches, sunlight, and pigeons. The multi-domed Basilica on one end, completed in 1094 but decorated for centuries afterward, is the final resting place of the apostle St. Mark, Venice’s patron saint. The mosaics beneath the basilica’s outside arches depict the arrival of St. Mark’s body, stolen from Egypt in 828 by Venetian traders. The frothy Venetian Gothic Doge’s Palace stands next door. Continue on to a glass-blowing demonstration. Venetian glass has long been considered the best in the world, and its production was such a state secret that during the Middle Ages, any Venetian glassblower who attempted to ply his trade outside the city was immediately arrested.

Stop in Verona to see the Romeo and Juliet Balcony. Verona is known primarily for its role as the setting for Shakespeare's Romeo and Juliet. The Montagues and Capulets were based on real feuding families, but were Romeo and Juliet real? A 14th-century house claims to be Juliet's--you can decide for yourself while gazing down at a statue of her from the balcony said to have inspired Shakespeare's famous balcony scene.

Immerse yourself in the charms of old-world Firenze, a red-brick splendor set in the rolling green hills of Tuscany. The birthplace and focal point of the Italian Renaissance, Florence still has the masterpieces to prove it. Brunelleschi’s elegant Duomo (dome) dominates the skyline, and around every corner is an architectural triumph filled with wall after wall of incomparable art. Your local licensed guide will take you to Giotto's Bell Tower and the aptly named Gates of Paradise, the bronze east doors of the Baptistery that spurred the burgeoning Renaissance. The boy guarding the Palazzo Vecchio with his slingshot is just a copy of Michelangelo’s David; the real statue is over at the Accademia. Don’t overlook the tombs of Michelangelo, Galileo, and Machiavelli at the Chiesa di Santa Croce, and definitely don’t overlook Florence’s amazing leather goods. Check them out when you visit one of the area’s famed workshops.

Stop in Pisa to see the famous leaning bell tower. It was already partly finished when builders realized that -- surprise! -- the ground beneath was too soft to support it. They tried to correct the tilt by putting a slight bend in the structure, but the extra weight just made it tilt more. Famous as it is, the leaning tower is just one component of Pisa’s Campo dei Miracoli (Field of Miracles). Rising from an immaculate green lawn, the baptistery, duomo, and tower are fine examples of Pisan Romanesque architecture. All three are clad in intricately carved black and white marble, and on bright summer days their brilliance can be blinding.

A small town of narrow streets and medieval walls, Assisi might never have been famous had it not been the birthplace of St. Francis, the founder of the Franciscan order. Today it is a major destination for religious pilgrims and art lovers alike. You’ll explore the Basilica of St. Francis, built in the 13th century to hold the saint’s body. Ironically, the body was hidden so well in the basilica that it took 600 years of digging to find it.

Baroque-en hearted? Revive your spirits with a walk past Rome's most beautiful and unusual Baroque fountains. At the foot of the Spanish Steps, elegant cafes once favored by visiting Brits and Americans surround the central fountain. The water pressure here was so low that the artist had to sink the fountain into the ground to get any water going through it, so he went ahead and designed the fountain to look like a sinking ship. There's no shortage of water pressure at the nearby Trevi Fountain, a Baroque extravagance designed by master sculptor Bernini. At the Pantheon you'll see the largest concrete dome ever constructed. An oculus, or hole, in the dome lets sunlight into the beautiful temple, dedicated to all the gods.

Gods and gladiators, glory and gore. Ancient Rome lives on in its spectacular monuments, flavoring the frenetic present with tastes of the past. Don a space-age Whisper headset to get the inside scoop on the most spectacular, the Colosseum, a grisly battle arena that seated more than 45,000. An enormous retractable roof awning system kept spectators cool on sunny days. The nearby Forum provides a glimpse into everyday ancient life, with markets, meeting places, and temples all combined into one vast space. Move into Christian Rome at St. Peter’s Basilica, the triumphal Renaissance church flanked by rows of columns radiating outward like welcoming arms. Within the church Michelangelo’s masterpieces are on display, the “Pietà” in the main church and the recently restored ceiling frescoes and “Last Judgment” in the Sistine Chapel. Continue your trek through time at Piazza Venezia, site of the enormous monument to Victor Emmanuel II, Italy’s first king, and of the Palazzo Venezia, where Mussolini set up his headquarters and from whose porch his mother was said to eavesdrop on citizens below. (The Sistine Chapel is closed on most religious holidays and Sundays, except for the last Sunday in each month).

Perched on the rocky cliffs overlooking the Bay of Naples, Sorrento is a beautiful resort town with stunning views of the sea. From here, the island of Capri is less than an hour away by boat. Always a favorite destination of the international jet-set, Capri still offers glittering beaches and old world glamour. Weather permitting, you’ll take a boat to the Blue Grotto, where sunlight reflected from beneath the water bathes the cave in a silver-blue light.

Travel from Sorrento to Brindisi, stopping to see the city where time stood still, literally. Once an important Roman city with 20,000 residents, Pompeii was frozen in time nearly 2000 years ago, when Mount Vesuvius erupted and buried the city under 30 feet of mud and volcanic ash. Forgotten for centuries after the eruption, Pompeii was discovered in the 1600s and is now completely excavated. On your tour you will learn how Romans of all classes lived their lives--not only from large public structures, but from details like political graffiti, bars, and street signs.

Once one of the most important sites in Greece, the former locale of the Olympic games now has some of the most picturesque ruins in the country. Surrounded by shady olive trees and flowing rivers, the stones of the original temple and stadium still inspire awe – and the occasional victory lap.

More than your usual roadside attractions. The route to Athens is paved with history, literally. Stop and see the sacred precinct of Epidaurus, a former health clinic and spa with a 4th-century BC amphitheater. Continue to Mycenae. Framed by twin mountains and looking out over the plains, Mycenae was a palace, a workshop and a grave. Gold cups, jewelry, bronze armor, swords and daggers, as described by Homer, were discovered here. Walk up to the remains of the citadel. Look out over the rolling hills. Imagine the bonfires blazing in all directions, signaling that Troy had fallen to Agamemnon. Continue on for a photo op at the Corinth Canal.

It’ll all be Greek to you. Head to a taverna in the Plaka to hear Greek music, weave through the steps of traditional Greek dancing, and sample such Greek favorites as souvlaki (a lamb sandwich), spanakopita (flaky phyllo dough filled with spinach and cheese), moussaka (Greek lasagna), and baklava (a phyllo, honey, and nut dessert). Opa!

Prophet from the past. Explore the impressive ruins at Delphi, which the Greeks considered the center of the world. Within the depths of the Temple of Apollo, a priestess would inhale intoxicating vapors that used to rise from the earth and, thus inspired, deliver the prophecies of Apollo. Modern visitors might find more inspiration in the view from Mount Parnassus, over 8000 feet high.

Not just another crowded dusty city, Athens has developed from the birthplace of democracy to a bustling modern metropolis. With a local licensed guide, start your time travel at the ancient hot spots of the first Olympic site and the sprawling Acropolis, classical Athens’ religious and civic center. The awe-inspiring Parthenon -- a temple dedicated to Athens’ patron saint Athena -- is the obvious centerpiece, but take time to examine the building next door, where sculpted women hold up the roof with their heads, and the amazing view of modern Athens below. Jump back to the present in Syntagma Square, the center of the modern city, to see the Parliament building and the British-style changing of the guards ceremony. (There’s a rather un-British flair to it, however -- the Greek guards wear white skirts, head scarves, and shoes and knee bands adorned with pom-poms.) Continue to Omonia Square, Athens' other main meeting point, to relax by the splashing central fountain ringed with palm trees.

The dynamic gateway between Europe and Asia, Istanbul straddles the two continents with grace. Open-air markets, little changed since the Ottoman Empire, offer silks, carpets, and spices, while cars speed past the modern hotels, cafés, and skyscrapers catering to the city’s newfound popularity as a tourist destination. Domes and minarets still dot the skyline, however, from the immense church of Hagia Sophia -- the absolute masterpiece of Byzantine architecture and the fourth-largest church in the world, with a dome 180 feet high -- to the beautiful Blue Mosque, designed for the 19-year-old Sultan Ahmet in 1609.

Now one of the most popular of the Aegean islands, Mykonos is rugged and beautiful at the same time, and is one of the smallest islands of the Cyclades – it’s only 10 miles long and 7 miles wide. Mykonos is absolutely picturesque - thatched windmills, whitewashed streets, and a medieval quarter boasting cubic houses with picturesque balconies, and churches with red or blue doors. You can walk along the main shopping street, Matoyanni, and search for jewelry and clothing, or just take a break in one of the cafes that line the street. You’ll also visit the capital, Hora, with its colorful harbor in which little fishing boats nest happily side by side with luxury yachts.

When he was exiled here for a year, Saint John the Evangelist was inspired to write the Book of Revelation by Patmos’s barren, haunting landscape. The monastery built to commemorate his stay still dominates the island. Inside the church are spectacular Byzantine icons and art, and from the hill on which it stands are incomparable views of the sparkling Aegean.

Once a political and religious center of the ancient world (and home of one of the seven wonders of the ancient world), Rhodes now lures visitors with sunny beaches, well-preserved medieval fortifications, and a castle on a hill. A league of Christian knights built the beautiful palace in the 1300s on the highest point of the island. Though partially destroyed by an explosion in 1856, the palace was rebuilt by the Italians to serve as one of Mussolini’s summer homes.

Rising steeply from the Aegean, crescent-shaped Santorini marks the rim of a volcanic crater that exploded in 1625 B.C., destroying and fragmenting a much larger island. The sea flooded into the crater, and now white towns gleam from the tops of the rocky cliffs, streaked black, brown, pink, and pale green. Rumors claim that this island may actually be the not-so-lost Atlantis.